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Why Dopamine Blockers Stop Nausea (And Cause Fatigue)
A listener with functional dyspepsia asks why dopamine-blocking drugs (like sulpiride and metoclopramide) kill his nausea but leave him exhausted the next day — and why his daily ADHD stimulant never makes him nauseous at all. We trace the area postrema, the brain's blood-barrier-free chemoreceptor trigger zone, and explain why nausea and vomiting aren't the same thing, why D2 blockade is both the cure and the side effect, and what separates a drug that crosses into the brain from one that stays in the gut. Plus: why metoclopramide has been the only FDA-approved gastroparesis drug since 1979…
The skinny
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