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The Alcohol-Depression Paradox: A Neurochemical Bridge
Why does alcohol — a central nervous system depressant — make clinical depression worse? The answer isn’t what most people assume. This episode unpacks the neurochemical bridge between CNS depression and major depressive disorder, revealing a surprising story of rebound, adaptation, and vicious cycles. We explore how alcohol and benzodiazepines suppress neural firing via GABA, how the brain fights back by remodeling itself, and why the crash that follows isn’t the drug effect continuing — it’s the backlash. From hangxiety to protracted withdrawal, from sleep architecture damage to emotional…
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