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Brain on Fire: The Science of the Kindling Effect
In this deep dive into addiction neuroscience, Herman and Corn explore the harrowing neurological phenomenon known as the kindling effect. They explain why successive bouts of alcohol withdrawal become increasingly severe, transforming from mild tremors into life-threatening emergencies. The discussion breaks down the delicate balance between GABA and glutamate, the role of "excitotoxicity" in damaging neurons, and the fascinating history of how researchers discovered that the brain can essentially "learn" how to have a seizure. From Graham Goddard’s early experiments to cutting-edge 2025…
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