When Supplements Make You Feel Worse (And Why It’s Not Random) | Dr. Tyler

The Evolving Wellness Podcast with Sarah Kleiner Wellness · Apr 8, 2026 · 1h 14m

Host Sarah interviews Dr. Tyler Panner, a PhD in cell biology and pharmacology, about why supplements can be life-changing for some people and harmful for others due to bioindividuality, genetics, and “terrain.” They discuss how stacking polyphenol supplements (e.g., curcumin, quercetin, resveratrol) can inhibit neurotransmitter breakdown and make adrenaline linger, worsening restlessness, anxiety, sleep, and irritability, and how concentrated products can also chelate iron and copper. They cover sulfur/sulfite sensitivity, histamine and glutamate “gas pedals,” confusing supplement blends…