Latest / Pearls and Prep / Bonus Episode: Brief, High-Yield Psych Case. A Board Question You Can’t Miss.
Transcript
- 0:00Foreign.
- 0:05Welcome
- 0:05back,
- 0:05my
- 0:06friends,
- 0:06to
- 0:06another
- 0:06episode
- 0:07of
- 0:07Pearls
- 0:08and
- 0:08Prep.
- 0:08This
- 0:08is
- 0:08NPZ
- 0:09here,
- 0:10your
- 0:10preceptor
- 0:10in
- 0:11your
- 0:11pocket,
- 0:11the
- 0:11go
- 0:11to
- 0:12place
- 0:12for
- 0:12pearls
- 0:13that
- 0:13prep
- 0:14you
- 0:14to
- 0:14practice.
- 0:15Well.
- 0:16Knock,
- 0:16knock,
- 0:16knock.
- 0:17You
- 0:18have
- 0:18a
- 0:1868
- 0:19year
- 0:19old
- 0:19woman
- 0:20with
- 0:20atrial
- 0:21fibrillation
- 0:22at
- 0:22your
- 0:22door
- 0:23in
- 0:23the
- 0:23outpatient
- 0:24clinic.
- 0:25She's
- 0:25on
- 0:25Apixaban,
- 0:265
- 0:27milligrams
- 0:27twice
- 0:28daily.
- 0:29And
- 0:29she
- 0:29has
- 0:30new
- 0:30onset
- 0:30depression.
- 0:31Her
- 0:31husband
- 0:32passed
- 0:32away
- 0:32three
- 0:33months
- 0:33ago.
- 0:34She's
- 0:34in
- 0:34tears.
- 0:35She's
- 0:35tried
- 0:36therapy,
- 0:36but
- 0:36she
- 0:36wants
- 0:37medications.
- 0:38Okay.
- 0:39Her
- 0:39PHQ9
- 0:39score
- 0:40is
- 0:4018.
- 0:40She
- 0:40has
- 0:41low
- 0:41energy.
- 0:41She's
- 0:42sleeping
- 0:42a
- 0:42lot,
- 0:43about
- 0:4312
- 0:43hours
- 0:43a
- 0:44day.
- 0:44And
- 0:45her
- 0:45appetite's
- 0:46actually
- 0:46increased.
- 0:46She's
- 0:47binging
- 0:47on
- 0:47Haagen
- 0:48Dazs.
- 0:49I'm
- 0:49more
- 0:49of
- 0:49a
- 0:49Ben
- 0:49and
- 0:49Jerry's
- 0:50fan.
- 0:50And
- 0:51she's
- 0:51feeling
- 0:51a
- 0:51little
- 0:51worthless
- 0:52now.
- 0:53She
- 0:53has
- 0:53no
- 0:53history
- 0:54of
- 0:54bleeding
- 0:54disorders
- 0:55or
- 0:55seizures.
- 0:56Now,
- 0:56which
- 0:56of
- 0:56the
- 0:57following
- 0:57is
- 0:57the
- 0:58most
- 0:58appropriate
- 0:58antidepressant
- 0:59choice
- 0:59for
- 1:00this
- 1:00patient?
- 1:00Would
- 1:01you
- 1:01give
- 1:01her
- 1:02Zoloft?
- 1:04That's
- 1:04a,
- 1:05B,
- 1:05Lexapro,
- 1:06C,
- 1:07Prozac,
- 1:07or
- 1:08D.
- 1:09Wellbutrin?
- 1:10So
- 1:11what
- 1:11would
- 1:11you
- 1:11do
- 1:11here,
- 1:12my
- 1:12friends?
- 1:14And
- 1:14the
- 1:15devil
- 1:15is
- 1:15in
- 1:15the
- 1:16details.
- 1:17So
- 1:18this
- 1:18is
- 1:18one
- 1:18of
- 1:18those
- 1:19questions
- 1:19that
- 1:20you
- 1:20may
- 1:20see
- 1:20on
- 1:20your
- 1:20boards,
- 1:21right?
- 1:22In
- 1:22where
- 1:22you
- 1:22have
- 1:22this
- 1:23kind
- 1:23of
- 1:24foreign
- 1:24medication
- 1:25you
- 1:25may
- 1:25not
- 1:25even
- 1:25understand
- 1:26or
- 1:26know
- 1:26about
- 1:27as
- 1:27a.
- 1:27As
- 1:27a
- 1:27new
- 1:27grad
- 1:28or
- 1:28someone
- 1:28preparing
- 1:29to
- 1:29practice.
- 1:29Right.
- 1:30A
- 1:30Pixaban.
- 1:31Okay.
- 1:32It's
- 1:32like,
- 1:32what
- 1:32on
- 1:32earth
- 1:33is
- 1:33that?
- 1:33Okay,
- 1:34but
- 1:34there
- 1:34are
- 1:34certain
- 1:35clues
- 1:35in
- 1:36here
- 1:36that
- 1:37are
- 1:37alluding
- 1:38to
- 1:38what
- 1:38it
- 1:38might
- 1:38do
- 1:40in
- 1:40a
- 1:40sneaky
- 1:41way.
- 1:41You
- 1:41know
- 1:41how
- 1:41these
- 1:41questions
- 1:42can
- 1:42get
- 1:42really
- 1:42sneaky
- 1:43on
- 1:43the
- 1:43boards
- 1:44or
- 1:44on
- 1:44your
- 1:44final
- 1:44exams?
- 1:45So
- 1:45there's
- 1:46something
- 1:46alluding
- 1:47to
- 1:47bleeding
- 1:48disorders
- 1:48or
- 1:48seizures.
- 1:49That's
- 1:49kind
- 1:49of
- 1:49a
- 1:49weird
- 1:50closing
- 1:51statement
- 1:51in
- 1:51your,
- 1:51in
- 1:52your
- 1:52opener
- 1:53here.
- 1:54But
- 1:54you
- 1:54do
- 1:54know
- 1:55she
- 1:55has
- 1:55atrial
- 1:55fibrillation.
- 1:56Okay.
- 1:57And
- 1:57this
- 1:58is
- 1:58where
- 1:58the
- 1:58pathophys
- 1:59class
- 2:00actually
- 2:00pays
- 2:00off
- 2:01in
- 2:01case
- 2:01you
- 2:01napped
- 2:02through
- 2:02it
- 2:03or
- 2:04you
- 2:04already
- 2:04threw
- 2:05your
- 2:05book
- 2:05in
- 2:05the
- 2:05chimney.
- 2:06Not
- 2:06a
- 2:06good
- 2:07idea.
- 2:07I
- 2:07don't
- 2:08recommend
- 2:08you
- 2:08do
- 2:08either
- 2:08of
- 2:08those
- 2:09things.
- 2:09I
- 2:09actually
- 2:09loved
- 2:09pathophys,
- 2:10but
- 2:11atrial
- 2:11fibrillation
- 2:12is
- 2:12kind
- 2:13of
- 2:13its
- 2:13own
- 2:13beast
- 2:13because
- 2:14with
- 2:14atrial
- 2:14fibrillation,
- 2:15you
- 2:16have
- 2:16the
- 2:16risk,
- 2:16of
- 2:17course,
- 2:17that
- 2:18your,
- 2:19your
- 2:19heart
- 2:20is
- 2:20not
- 2:21beating
- 2:22in
- 2:22a
- 2:22normal
- 2:22rhythm
- 2:23and
- 2:23it
- 2:23can
- 2:23actually
- 2:24lead
- 2:24to
- 2:25the
- 2:26formation
- 2:27of
- 2:27clots.
- 2:28Okay.
- 2:29And
- 2:30so
- 2:30apixaban
- 2:31is
- 2:31a
- 2:31direct
- 2:31oral
- 2:32anti
- 2:33coagulant.
- 2:34Good
- 2:34to
- 2:34know.
- 2:34Right.
- 2:35And
- 2:36so
- 2:36it
- 2:36kind
- 2:36of
- 2:37prevents
- 2:37thrombin
- 2:38generation
- 2:38and
- 2:38clot
- 2:39formation.
- 2:40It's
- 2:41first
- 2:41line
- 2:41therapy
- 2:41for
- 2:41stroke
- 2:42prevention
- 2:43in
- 2:43afib
- 2:44reduces
- 2:44stroke
- 2:45by
- 2:4555%.
- 2:46Okay?
- 2:47You
- 2:47don't
- 2:47need
- 2:47to
- 2:47know
- 2:47that
- 2:47much
- 2:48more.
- 2:48You
- 2:48don't
- 2:48need
- 2:48to
- 2:48know
- 2:48who
- 2:48invented
- 2:49it.
- 2:49You
- 2:50don't
- 2:50need
- 2:50to
- 2:50know
- 2:50whose
- 2:51grandmother
- 2:51is
- 2:51on
- 2:52this
- 2:52right
- 2:52now.
- 2:53But
- 2:53the
- 2:53grandmother
- 2:53at
- 2:54your
- 2:54door
- 2:54in
- 2:54the
- 2:55outpatient
- 2:55space
- 2:56is
- 2:56on
- 2:56this.
- 2:57And
- 2:58it's
- 2:58really
- 2:58important,
- 2:59you
- 2:59know?
- 2:59And
- 2:59you
- 3:00kind
- 3:00of
- 3:00stop
- 3:00in
- 3:00your
- 3:00tracks
- 3:01and
- 3:01go,
- 3:01wait
- 3:01a
- 3:01minute.
- 3:02Is
- 3:02there
- 3:02anything
- 3:02I
- 3:03need
- 3:03to
- 3:03know
- 3:03here?
- 3:03One
- 3:04of
- 3:04my
- 3:04golden
- 3:04rules
- 3:05in
- 3:05practice,
- 3:05my
- 3:06friends,
- 3:06is
- 3:07I
- 3:07always
- 3:07like
- 3:07to
- 3:08ask
- 3:08myself,
- 3:09what
- 3:09is
- 3:09the
- 3:09worst
- 3:10possible
- 3:10thing
- 3:11I
- 3:11could
- 3:12do
- 3:12here,
- 3:12and
- 3:13how
- 3:13do
- 3:13I
- 3:13not
- 3:13do
- 3:13that?
- 3:14Right?
- 3:14And
- 3:15so
- 3:15when
- 3:15I
- 3:15frame
- 3:16the
- 3:16question
- 3:16like
- 3:16that
- 3:17after
- 3:18seeing
- 3:18a
- 3:18patient
- 3:19or
- 3:19being
- 3:19in
- 3:19front
- 3:19of
- 3:19a
- 3:20patient,
- 3:20it
- 3:21allows
- 3:21me
- 3:21to
- 3:22really
- 3:22scrutinize,
- 3:22almost
- 3:23like
- 3:23a
- 3:23detective,
- 3:23like,
- 3:24what
- 3:24is.
- 3:24What
- 3:24is
- 3:25going
- 3:25on
- 3:25here?
- 3:26What
- 3:26do
- 3:26I
- 3:26have
- 3:26to
- 3:26be
- 3:27worried
- 3:27about?
- 3:28And
- 3:28certainly
- 3:28somebody
- 3:29with
- 3:29atrial
- 3:29fibrillation.
- 3:30I'd
- 3:30want
- 3:30to
- 3:31do
- 3:31a
- 3:31deeper
- 3:31dive
- 3:31and
- 3:32understand,
- 3:32like,
- 3:32what
- 3:33is
- 3:33the
- 3:33worst
- 3:33thing
- 3:33I
- 3:33could
- 3:34accidentally
- 3:34do
- 3:34here
- 3:35if
- 3:35I'm
- 3:35not
- 3:35paying
- 3:35attention.
- 3:36Okay?
- 3:37And
- 3:37so
- 3:38of
- 3:38all
- 3:38these.
- 3:39Of
- 3:39all
- 3:39these
- 3:39answers,
- 3:40right?
- 3:40Zoloft,
- 3:41Lexapro,
- 3:42Prozac,
- 3:43or.
- 3:44Or
- 3:44Wellbutrin,
- 3:46which
- 3:46one
- 3:47of
- 3:47these
- 3:47things
- 3:47is
- 3:47not
- 3:48like
- 3:48the
- 3:48other,
- 3:48Right?
- 3:49Well,
- 3:49right
- 3:49off
- 3:49the
- 3:49bat,
- 3:50we
- 3:50have
- 3:50three
- 3:50SSRIs,
- 3:51and
- 3:51then
- 3:51we
- 3:52have
- 3:52one
- 3:52NDRI.
- 3:53NDRI
- 3:53would
- 3:53be
- 3:54Wellbutrin.
- 3:54It's
- 3:54a
- 3:54norepinephrine
- 3:55dopamine
- 3:56reuptake
- 3:56inhibitor.
- 3:58Well,
- 3:58why
- 3:58do
- 3:58we
- 3:58have
- 3:58one?
- 3:59Dopamine,
- 3:59norepinephrine
- 4:00reuptake
- 4:01inhibitor,
- 4:01choice.
- 4:02And
- 4:02the
- 4:02rest
- 4:03are
- 4:03serotonergic.
- 4:04Well,
- 4:04that's
- 4:04interesting,
- 4:05because
- 4:05we're
- 4:05supposed
- 4:05to
- 4:05pick
- 4:05one
- 4:06that
- 4:06is
- 4:06good,
- 4:07one
- 4:07that
- 4:07is
- 4:07acceptable
- 4:08to
- 4:08the
- 4:08patient.
- 4:10Well,
- 4:11that's
- 4:12very
- 4:12interesting.
- 4:13Well,
- 4:13we
- 4:13know,
- 4:13right,
- 4:14when
- 4:14a
- 4:15patient
- 4:15is
- 4:15taking
- 4:15oral
- 4:16anticoagulants,
- 4:17right?
- 4:17So
- 4:17we're
- 4:18trying
- 4:18to
- 4:18bust
- 4:18up
- 4:18clots.
- 4:19There
- 4:19is
- 4:20a
- 4:20concern
- 4:21for
- 4:21bleeding,
- 4:23and
- 4:24one
- 4:24of
- 4:24the
- 4:25side
- 4:25effects
- 4:26or
- 4:27one
- 4:27of
- 4:27the
- 4:27contraindications
- 4:28with
- 4:29SSRIs
- 4:30is
- 4:30that
- 4:30they
- 4:30can
- 4:30increase
- 4:31bleeding
- 4:31risk
- 4:32with
- 4:32anticoagulants.
- 4:33Right?
- 4:34SSRIs
- 4:34deplete
- 4:35platelet
- 4:35serotonin,
- 4:36so
- 4:37they
- 4:37kind
- 4:37of
- 4:37make
- 4:37that
- 4:37clot
- 4:38formation.
- 4:38They
- 4:39kind
- 4:39of
- 4:39give
- 4:40it
- 4:40less
- 4:40glue
- 4:40to
- 4:41clot,
- 4:41and
- 4:42so
- 4:42bleeding
- 4:42can
- 4:43happen
- 4:43more
- 4:44frequently.
- 4:44That's
- 4:45a
- 4:45problem.
- 4:45Right?
- 4:46It
- 4:46can
- 4:46be
- 4:46harder
- 4:47to
- 4:47control
- 4:47bleeding.
- 4:48Patients
- 4:48can
- 4:49bruise
- 4:49easily.
- 4:49They
- 4:49can
- 4:50get
- 4:50nosebleeds.
- 4:50They
- 4:51can
- 4:51have
- 4:51bleeding
- 4:51gums,
- 4:52heavier
- 4:52periods,
- 4:53you
- 4:53know,
- 4:53if
- 4:54it's
- 4:54moderate.
- 4:54And
- 4:55if
- 4:55it's
- 4:55escalating,
- 4:56they
- 4:56might
- 4:56have
- 4:56black
- 4:56stools
- 4:57or
- 4:57fatigue
- 4:57and
- 4:57become
- 4:58anemic.
- 4:58Okay,
- 5:00um.
- 5:00That's
- 5:01a
- 5:01problem
- 5:01as
- 5:01well,
- 5:02right?
- 5:02Uh,
- 5:03they
- 5:04might.
- 5:05In
- 5:05the
- 5:05worst
- 5:06case
- 5:06scenario,
- 5:06your
- 5:07elderly
- 5:07patient
- 5:08falls,
- 5:09hits
- 5:09her
- 5:09head,
- 5:10and
- 5:10now
- 5:10there's
- 5:11an
- 5:11intra.
- 5:11Intracranial
- 5:12bleed
- 5:12because
- 5:13we
- 5:13prescribed
- 5:14Zoloft
- 5:15or
- 5:15Prozac
- 5:16when
- 5:16they
- 5:16were
- 5:17also
- 5:17on
- 5:17an
- 5:17anticoagulant.
- 5:19So
- 5:19with
- 5:19older
- 5:20patients,
- 5:20of
- 5:20course,
- 5:20there's
- 5:21many
- 5:21different
- 5:21patients
- 5:21you
- 5:22have
- 5:22to
- 5:22be
- 5:22careful
- 5:22with
- 5:23when
- 5:23it
- 5:23comes
- 5:23to
- 5:24bleeding
- 5:25risks.
- 5:25But
- 5:25with
- 5:26older
- 5:26patients,
- 5:26we're
- 5:27definitely
- 5:27concerned
- 5:27about
- 5:28the
- 5:28fall.
- 5:28And
- 5:29it's
- 5:29even
- 5:29worse
- 5:30if
- 5:30you,
- 5:30if
- 5:30you
- 5:30prescribe
- 5:31like
- 5:31a
- 5:31sedating
- 5:32ssri,
- 5:32God
- 5:33forbid
- 5:33you
- 5:33prescribe
- 5:33Paxil,
- 5:34which
- 5:35I
- 5:35think
- 5:35by
- 5:35the
- 5:36time
- 5:36you
- 5:36start
- 5:37practicing,
- 5:38I
- 5:38hope
- 5:39you
- 5:39all
- 5:39will
- 5:40have
- 5:40the
- 5:40intuition
- 5:41to
- 5:41go.
- 5:41Paxil
- 5:42is
- 5:42really
- 5:42not
- 5:43a
- 5:43good
- 5:43idea
- 5:43in
- 5:44older
- 5:44folks
- 5:45because
- 5:45especially
- 5:46if
- 5:46there's
- 5:46like
- 5:46a
- 5:47anticoagulant
- 5:48on
- 5:48board,
- 5:49because
- 5:49not
- 5:50only
- 5:50is
- 5:50there
- 5:51an
- 5:51increased
- 5:51risk
- 5:51of
- 5:51bleeding,
- 5:52but
- 5:52this
- 5:52is
- 5:52quite
- 5:53sedating.
- 5:54This
- 5:54patient
- 5:54that
- 5:55you're.
- 5:55That's
- 5:55at
- 5:55your
- 5:56clinic
- 5:56right
- 5:56now
- 5:56gained
- 5:5715
- 5:57pounds
- 5:57of
- 5:57weight.
- 5:57So
- 5:58Paxil's
- 5:58even
- 5:58worse.
- 5:59Now
- 5:59you're
- 6:00going
- 6:00to
- 6:00cause
- 6:00weight
- 6:00gain.
- 6:00Now
- 6:01you're
- 6:01going
- 6:01to
- 6:01cause
- 6:01a
- 6:01bleed
- 6:02risk,
- 6:03and
- 6:03the
- 6:03patient's
- 6:04going
- 6:04to
- 6:04be
- 6:04sedated
- 6:05and
- 6:05might
- 6:05fall
- 6:05and
- 6:06has
- 6:06a
- 6:06worse
- 6:06bleed
- 6:07risk.
- 6:07Right?
- 6:07So
- 6:08Paxil
- 6:08would
- 6:08be
- 6:08one
- 6:09of
- 6:09the
- 6:09worst
- 6:09things
- 6:09you
- 6:09could
- 6:10do,
- 6:10which.
- 6:11Which
- 6:11would
- 6:11be
- 6:12horrific.
- 6:12But,
- 6:13yeah.
- 6:13So
- 6:13Paxil's
- 6:14a
- 6:14bad
- 6:14idea,
- 6:14but
- 6:14sometimes
- 6:15you
- 6:15learn
- 6:16in
- 6:16school
- 6:17by
- 6:18understanding
- 6:18what
- 6:18the
- 6:19worst
- 6:19thing
- 6:19is.
- 6:19So
- 6:19you
- 6:20understand
- 6:20what
- 6:20the
- 6:20best
- 6:20thing
- 6:21is,
- 6:21right?
- 6:22And
- 6:23so,
- 6:23my
- 6:24friends,
- 6:25the
- 6:25answer
- 6:26today
- 6:26to
- 6:27this
- 6:27question
- 6:28is
- 6:28Wellbutrin.
- 7:24Because
- 7:25sure
- 7:26enough,
- 7:26Wellbutrin
- 7:27is
- 7:27the
- 7:28non
- 7:28serotonergic
- 7:29choice
- 7:30that
- 7:30will
- 7:30not
- 7:31lead
- 7:31to
- 7:31an
- 7:31increased
- 7:32risk
- 7:32of
- 7:33bleeding.
- 7:34Okay?
- 7:34It's
- 7:35also
- 7:35convenient
- 7:36for
- 7:36her
- 7:36particular
- 7:37symptoms,
- 7:37right?
- 7:38Her
- 7:38low
- 7:38energy,
- 7:39she's
- 7:39sleeping
- 7:40too
- 7:40much,
- 7:42she
- 7:42has
- 7:42an
- 7:42increased
- 7:42appetite,
- 7:43she's
- 7:43gaining
- 7:43weight.
- 7:44Wellbutrin
- 7:45typically
- 7:45is
- 7:45weight
- 7:45neutral.
- 7:46Some
- 7:46people
- 7:46even
- 7:46lose
- 7:47weight
- 7:47on
- 7:47Wellbutrin
- 7:48in
- 7:48my
- 7:48experience.
- 7:49But
- 7:49it
- 7:49certainly
- 7:50will
- 7:50give
- 7:50her
- 7:50that
- 7:50energy.
- 7:51Now
- 7:51you
- 7:51just
- 7:51have
- 7:51to
- 7:52make
- 7:52sure
- 7:52she
- 7:52has
- 7:52no
- 7:52seizure
- 7:53history.
- 7:53And
- 7:53of
- 7:53course,
- 7:54we
- 7:54proved
- 7:55that.
- 7:55And
- 7:55there's
- 7:56a
- 7:56little
- 7:56clue,
- 7:56my
- 7:56friend.
- 7:57See,
- 7:57when
- 7:57you
- 7:58put
- 7:58this
- 7:58all
- 7:58together,
- 7:58when
- 7:59you
- 7:59read
- 7:59the
- 7:59whole
- 7:59question,
- 7:59it
- 8:00really
- 8:00helps
- 8:00you
- 8:00gain
- 8:01mastery
- 8:01in
- 8:01your
- 8:01board
- 8:02questions,
- 8:02because
- 8:03the
- 8:03Wellbutrin
- 8:04here,
- 8:05right,
- 8:06it's
- 8:06like
- 8:06a
- 8:06clue
- 8:06at
- 8:07the
- 8:07end
- 8:07of
- 8:07your.
- 8:08At
- 8:08the
- 8:08end
- 8:08of
- 8:08this
- 8:09multiple
- 8:09choice
- 8:09question
- 8:10says
- 8:10she
- 8:10has
- 8:10no
- 8:10history
- 8:10of
- 8:11bleeding
- 8:11disorders
- 8:11or
- 8:12seizures.
- 8:12Usually
- 8:13questions
- 8:14don't
- 8:14just
- 8:14throw
- 8:14irrelevant
- 8:15information
- 8:15at
- 8:16you,
- 8:16okay?
- 8:16There's
- 8:16usually
- 8:17a
- 8:17reason
- 8:17they're
- 8:18telling
- 8:18you
- 8:18she
- 8:18has
- 8:18no
- 8:19History
- 8:19of
- 8:19seizures.
- 8:20That's
- 8:20the
- 8:20elbow
- 8:21nudge
- 8:21saying,
- 8:21hey,
- 8:21if
- 8:22you're
- 8:22going
- 8:22to
- 8:22consider
- 8:22Wellbutrin,
- 8:24it
- 8:24ain't
- 8:24a
- 8:24bad
- 8:24choice
- 8:25because
- 8:25she
- 8:25doesn't
- 8:25have
- 8:26a
- 8:26history
- 8:26of
- 8:26seizures.
- 8:27So
- 8:28absolutely
- 8:28the
- 8:28right
- 8:29thing
- 8:29to
- 8:29do
- 8:29here
- 8:30with
- 8:30your
- 8:30elderly
- 8:31fit
- 8:31patient
- 8:32is
- 8:32set
- 8:32her
- 8:32up
- 8:32for
- 8:32success,
- 8:33make
- 8:33sure
- 8:33she's
- 8:34safe,
- 8:34and
- 8:35avoid
- 8:35the
- 8:35SSRIs,
- 8:38because
- 8:38we
- 8:38don't
- 8:38want
- 8:39to
- 8:39impair
- 8:39platelet
- 8:40aggregation.
- 8:42And
- 8:42we,
- 8:43you
- 8:43know,
- 8:43remember
- 8:44that
- 8:44platelets
- 8:44themselves
- 8:45cannot
- 8:45synthesize
- 8:46serotonin,
- 8:47okay?
- 8:47They
- 8:48rely
- 8:48entirely
- 8:49on
- 8:49the
- 8:49uptake
- 8:50from
- 8:50plasma
- 8:50via
- 8:51SS,
- 8:51the.
- 8:51The
- 8:52SSRI
- 8:52via
- 8:53the
- 8:53serotonin
- 8:53transporter,
- 8:54okay?
- 8:55Which
- 8:55SSRIs
- 8:56block,
- 8:56okay?
- 8:57So
- 8:58that's
- 8:58a
- 8:58big
- 8:58issue.
- 8:59So
- 8:59remember,
- 8:59platelets
- 9:00are
- 9:00very
- 9:00needy.
- 9:02They're
- 9:02very
- 9:02needy
- 9:03for
- 9:04serotonin.
- 9:05And
- 9:05the
- 9:05SSRI
- 9:06really
- 9:06stops
- 9:07the
- 9:07show.
- 9:07And
- 9:08that's
- 9:08a
- 9:08major
- 9:08problem.
- 9:10So
- 9:10we
- 9:10wanna
- 9:10just
- 9:11keep
- 9:11that
- 9:11in
- 9:11mind.
- 9:12We
- 9:12don't
- 9:12want
- 9:13intracranial
- 9:13hemorrhages,
- 9:14GI
- 9:14bleeding,
- 9:15any
- 9:15major
- 9:15bleeds
- 9:15at
- 9:16all.
- 9:16And
- 9:16look
- 9:16out
- 9:17for
- 9:17warfarin,
- 9:17right?
- 9:18Look
- 9:18out
- 9:18for
- 9:19all
- 9:19these
- 9:19other
- 9:20medications
- 9:20out
- 9:20there.
- 9:20There's
- 9:21a
- 9:21lot
- 9:21of
- 9:21oral
- 9:21anticoagulants
- 9:22I
- 9:22highly
- 9:23recommend
- 9:23you
- 9:24get
- 9:24familiar
- 9:24with.
- 9:24Cause
- 9:25I'll
- 9:25tell
- 9:25you
- 9:25something,
- 9:25my
- 9:25friends,
- 9:26pharmacology,
- 9:27at
- 9:27least
- 9:28in
- 9:28my
- 9:28experience
- 9:28at
- 9:28school,
- 9:29was
- 9:29challenging
- 9:30because
- 9:30there's
- 9:30a
- 9:30lot
- 9:31of
- 9:31medications.
- 9:31The
- 9:32mnemonics
- 9:32weren't
- 9:33great.
- 9:33You're
- 9:34memorizing
- 9:3420
- 9:35different
- 9:35skin,
- 9:35you
- 9:36know,
- 9:36dermatological
- 9:37medications,
- 9:3920
- 9:39different
- 9:39anticoagulants.
- 9:40It
- 9:41can
- 9:41be
- 9:41kind
- 9:41of
- 9:41blurry
- 9:41and
- 9:42scary.
- 9:42And
- 9:42I
- 9:42will
- 9:43say
- 9:43one
- 9:43thing
- 9:43that
- 9:44you
- 9:44really
- 9:44could,
- 9:45one
- 9:45thing
- 9:46that
- 9:46would
- 9:46really
- 9:46prepare
- 9:46you
- 9:47before
- 9:47you
- 9:47go
- 9:47into
- 9:47practice
- 9:48is
- 9:49memorizing
- 9:50some
- 9:51of
- 9:51the
- 9:51most
- 9:52relevant
- 9:53medications
- 9:54that
- 9:55are
- 9:55medical,
- 9:56that
- 9:56can
- 9:56interfere,
- 9:57that
- 9:57psychiatric
- 9:57medications
- 9:58can
- 9:58interfere
- 9:59with.
- 9:59Right?
- 10:00So
- 10:00I
- 10:00don't
- 10:00know
- 10:01if
- 10:01you
- 10:01want
- 10:01to
- 10:01consult
- 10:01open
- 10:02evidence.
- 10:02It's
- 10:02a
- 10:02really
- 10:03great
- 10:04AI
- 10:04tool
- 10:04that's
- 10:05backed
- 10:05by,
- 10:06you
- 10:07know,
- 10:07JAMA
- 10:08and
- 10:08the
- 10:08BMJ
- 10:09and
- 10:09all
- 10:09kinds
- 10:09of
- 10:09really
- 10:10good
- 10:10evidence
- 10:10based
- 10:10literature.
- 10:11But
- 10:11that's
- 10:12kind
- 10:12of
- 10:12an
- 10:12AI
- 10:12that's
- 10:13backed
- 10:13specifically
- 10:14by
- 10:14peer
- 10:14reviewed
- 10:15literature.
- 10:15And
- 10:16ask
- 10:16it,
- 10:17you
- 10:17know,
- 10:17throw
- 10:17it
- 10:17a
- 10:17few
- 10:17prompts
- 10:18and
- 10:18give
- 10:18me
- 10:18the
- 10:1820
- 10:19most
- 10:19high
- 10:19yield
- 10:21medications
- 10:22that
- 10:23people
- 10:23may
- 10:23be
- 10:24on
- 10:24that
- 10:24psych,
- 10:25NPS
- 10:25or
- 10:25psychiatrists
- 10:27may
- 10:27not
- 10:27be
- 10:27as
- 10:27acutely
- 10:28familiar
- 10:28with
- 10:29when
- 10:29they
- 10:29graduate
- 10:30to
- 10:30ensure
- 10:30that
- 10:31I'm
- 10:31being
- 10:31very
- 10:31vigilant
- 10:32about
- 10:33anything
- 10:33that's
- 10:33coming
- 10:34into
- 10:34my
- 10:35clinic,
- 10:35right?
- 10:35Just
- 10:36to
- 10:36get
- 10:36a
- 10:36brush
- 10:36up.
- 10:36They
- 10:37call
- 10:37this
- 10:37practice
- 10:37for
- 10:37a
- 10:38reason.
- 10:38It
- 10:38didn't
- 10:39occur
- 10:39to
- 10:39me
- 10:40for
- 10:40a
- 10:40couple
- 10:41of
- 10:41years
- 10:41until
- 10:41I
- 10:41graduated.
- 10:43What
- 10:43practice
- 10:44really
- 10:44means,
- 10:44right?
- 10:45When
- 10:45you're
- 10:45Practicing
- 10:45an
- 10:46instrument,
- 10:46you're
- 10:47getting
- 10:47better
- 10:47every
- 10:47time.
- 10:48That
- 10:48means
- 10:48that
- 10:48it
- 10:49requires
- 10:49a
- 10:49daily
- 10:49discipline
- 10:50to
- 10:50improve,
- 10:50to
- 10:51research,
- 10:51to
- 10:52refine.
- 10:52Don't
- 10:53be
- 10:54self
- 10:54conscious
- 10:54or
- 10:54insecure
- 10:55if
- 10:55you
- 10:55don't
- 10:56remember
- 10:56every,
- 10:56the
- 10:57name
- 10:57of
- 10:57every
- 10:57oral
- 10:57anti
- 10:58coagulant
- 10:58off
- 10:58the
- 10:59top
- 10:59of
- 10:59your
- 10:59head.
- 10:59Especially
- 11:00with
- 11:00the,
- 11:00considering
- 11:01the
- 11:01fact
- 11:01that
- 11:01there's
- 11:02new
- 11:02ones
- 11:02that
- 11:02come
- 11:02out
- 11:03all
- 11:03of
- 11:03the
- 11:03time,
- 11:03there's
- 11:04new
- 11:04meds
- 11:04that
- 11:04come
- 11:04out
- 11:05all
- 11:05of
- 11:05the
- 11:05time.
- 11:05No
- 11:06one
- 11:06can
- 11:06keep
- 11:06track
- 11:06of
- 11:07all
- 11:07of
- 11:07that.
- 11:07But
- 11:08that's
- 11:08why
- 11:08we
- 11:08call
- 11:08this
- 11:08a
- 11:09practice
- 11:09every
- 11:09day.
- 11:10We,
- 11:10we
- 11:10have,
- 11:11you
- 11:11know,
- 11:11we,
- 11:11we
- 11:11have
- 11:12the
- 11:12discipline
- 11:13and
- 11:13the,
- 11:15you
- 11:15know,
- 11:15the,
- 11:15the
- 11:16persistence
- 11:16to,
- 11:17to,
- 11:17to
- 11:17get,
- 11:18get
- 11:18on
- 11:18the
- 11:18instrument
- 11:19and
- 11:19play
- 11:19and,
- 11:20and
- 11:20pretty
- 11:20soon
- 11:20we're
- 11:21really
- 11:21proud
- 11:21of
- 11:22the
- 11:22way
- 11:22we
- 11:22sound
- 11:23and
- 11:23we
- 11:23keep
- 11:23playing
- 11:24and
- 11:24performing
- 11:25and
- 11:25we're
- 11:25doing
- 11:25well.
- 11:26So
- 11:26think
- 11:26of
- 11:27it
- 11:27that
- 11:27way.
- 11:27My
- 11:27friends
- 11:28run
- 11:29these
- 11:29queries,
- 11:31find
- 11:31out
- 11:31the
- 11:31medications
- 11:32that
- 11:32you
- 11:32really
- 11:33need
- 11:33to
- 11:33be
- 11:33careful
- 11:33about.
- 11:34And
- 11:34I'll
- 11:34tell
- 11:34you,
- 11:35you
- 11:35might
- 11:35find
- 11:35your
- 11:3675
- 11:36year
- 11:36old
- 11:36patients
- 11:37are
- 11:37on
- 11:3730
- 11:37different
- 11:38medications.
- 11:39It
- 11:39can
- 11:39be
- 11:39very
- 11:39dizzying,
- 11:40it
- 11:40can
- 11:40be
- 11:40very
- 11:40overwhelming.
- 11:42It's
- 11:42very
- 11:42important.
- 11:42You
- 11:43have
- 11:43a
- 11:43working
- 11:43familiarity
- 11:44with
- 11:45some
- 11:45of
- 11:45the
- 11:45worst
- 11:45things
- 11:46that
- 11:46can
- 11:46happen
- 11:46in
- 11:46those
- 11:47populations.
- 11:47And
- 11:47it
- 11:48may
- 11:48not
- 11:48be
- 11:48always
- 11:48that
- 11:49simple.
- 11:49You
- 11:49might
- 11:49have
- 11:49a
- 11:50patient
- 11:50who
- 11:50comes
- 11:51into
- 11:51your
- 11:51office
- 11:51who
- 11:52not
- 11:52only
- 11:53is
- 11:54on,
- 11:55you
- 11:55know,
- 11:55not
- 11:55only
- 11:55has
- 11:56afib
- 11:56and,
- 11:57but,
- 11:57but
- 11:58also
- 11:58has
- 11:58seizures
- 11:59in
- 11:59her
- 11:59past.
- 11:59Well,
- 12:00now
- 12:00you
- 12:00can't
- 12:00give
- 12:00Wellbutrin.
- 12:01So
- 12:01what
- 12:01do
- 12:01you
- 12:02do
- 12:02then,
- 12:03right?
- 12:03Do
- 12:04you
- 12:04go
- 12:04to
- 12:04psychotherapy?
- 12:05Is
- 12:05this
- 12:05something
- 12:05that
- 12:05psychotherapy
- 12:06can
- 12:06handle?
- 12:07Psychotherapy
- 12:07has
- 12:07a
- 12:07good
- 12:08effect
- 12:08size,
- 12:09right.
- 12:09It's
- 12:10perfectly
- 12:10appropriate
- 12:11to
- 12:11treat
- 12:12depression
- 12:13or
- 12:13grief.
- 12:13You
- 12:14know,
- 12:14she
- 12:14lost
- 12:14her
- 12:14husband
- 12:15three
- 12:15months
- 12:15ago.
- 12:15Maybe
- 12:16you,
- 12:16maybe
- 12:16you
- 12:17orient
- 12:18her
- 12:18to
- 12:18like
- 12:18grief
- 12:18counseling
- 12:19or
- 12:19a
- 12:19group.
- 12:20Group
- 12:20therapy.
- 12:20Grief
- 12:21group
- 12:21or
- 12:22a
- 12:22therapist
- 12:22who
- 12:23specializes
- 12:23in
- 12:24grief.
- 12:24Right?
- 12:25I
- 12:26mean
- 12:26her
- 12:26PHQ9
- 12:27score
- 12:27is
- 12:27high,
- 12:28you
- 12:29know,
- 12:29so
- 12:29you.
- 12:29But
- 12:30there's
- 12:30other
- 12:30ways
- 12:30to
- 12:31skin
- 12:31the
- 12:31cat,
- 12:31right?
- 12:31We
- 12:32don't
- 12:32necessarily
- 12:32have
- 12:33to
- 12:33go
- 12:33to
- 12:33ssri.
- 12:34There's
- 12:34non
- 12:35serotonergic
- 12:36paths
- 12:37to,
- 12:39to
- 12:39treat
- 12:39her
- 12:39depression,
- 12:40which
- 12:40I
- 12:40think
- 12:40are
- 12:41very
- 12:41important.
- 12:42Okay.
- 12:43You
- 12:43want
- 12:44to
- 12:44run
- 12:44labs,
- 12:44obviously
- 12:45make
- 12:45sure
- 12:45that
- 12:46the
- 12:46depression
- 12:47isn't
- 12:47being
- 12:47manifested
- 12:48in
- 12:48other
- 12:48ways.
- 12:49How's
- 12:49her
- 12:49thyroid?
- 12:50How's
- 12:50her
- 12:50vitamin
- 12:50d?
- 12:50How's
- 12:51her
- 12:51B12
- 12:51and
- 12:51folate,
- 12:52et
- 12:52cetera,
- 12:53et
- 12:53cetera,
- 12:53et
- 12:53cetera.
- 12:54Hopefully
- 12:54those
- 12:54are
- 12:54the
- 12:54things
- 12:55driving
- 12:55her
- 12:55depression
- 12:56because
- 12:57you're
- 12:57kind
- 12:57of
- 12:57getting
- 12:58a
- 12:58slim
- 12:58pickings
- 12:59when
- 12:59you
- 12:59don't
- 12:59have
- 12:59SSRIs
- 13:00or
- 13:00Wellbutrin
- 13:01to
- 13:01prescribe.
- 13:02So
- 13:02I
- 13:02hope
- 13:02you
- 13:02appreciated
- 13:03this
- 13:03little
- 13:03case
- 13:03study
- 13:04today
- 13:05and
- 13:05definitely
- 13:06share
- 13:06it
- 13:06and
- 13:06enjoy
- 13:07it.
- 13:07These
- 13:08are
- 13:08the
- 13:08kind
- 13:08of
- 13:08ones
- 13:08that
- 13:08keep
- 13:09us
- 13:09on
- 13:09our
- 13:09toes
- 13:09and
- 13:10make
- 13:10us
- 13:10better
- 13:11at
- 13:11what
- 13:11we
- 13:11do.
- 13:11And
- 13:11remember,
- 13:12my
- 13:12friends,
- 13:13if
- 13:13you
- 13:14really
- 13:14want
- 13:14to
- 13:14stand
- 13:15out
- 13:15as
- 13:15a
- 13:15clinician
- 13:16and
- 13:16feel
- 13:16confident
- 13:17on
- 13:17details
- 13:18without
- 13:18getting
- 13:18stuck
- 13:19in
- 13:19front
- 13:19of
- 13:19your
- 13:19patient,
- 13:20check
- 13:20out
- 13:20our
- 13:20Patreon
- 13:21membership
- 13:21in
- 13:22the
- 13:22show
- 13:22notes.
- 13:23That's
- 13:23where
- 13:23we
- 13:24do
- 13:24deep
- 13:24case
- 13:25breakdowns,
- 13:26medication,
- 13:26deep
- 13:26dives,
- 13:27and
- 13:27gritty
- 13:28weekly
- 13:29street
- 13:29pearls,
- 13:29all
- 13:30organized
- 13:30so
- 13:30you
- 13:30can
- 13:31actually
- 13:31see
- 13:31them
- 13:31and
- 13:31use
- 13:32them.
- 13:32It's
- 13:32next
- 13:33next
- 13:33level
- 13:33stuff.
- 13:34It's
- 13:34it's
- 13:34about
- 13:35being
- 13:35confident
- 13:35in
- 13:36front
- 13:36of
- 13:36who
- 13:36you're
- 13:37in
- 13:37front
- 13:37of
- 13:37your
- 13:37patients.
- 13:38So
- 13:38you
- 13:38develop
- 13:39a
- 13:39mastery
- 13:39and
- 13:39an
- 13:40edge
- 13:40in
- 13:40the
- 13:40field.
- 13:41And
- 13:41that's
- 13:41what
- 13:41Patreon
- 13:42is
- 13:42for.
- 13:43All
- 13:43right,
- 13:43my
- 13:43friends,
- 13:44without
- 13:44further
- 13:44ado,
- 13:45have
- 13:45a
- 13:45great
- 13:46Sunday.
- 13:46See
- 13:46you
- 13:47next
- 13:47time
- 13:47on
- 13:47Pearls
- 13:48and
- 13:48Prep.