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Why Isn't Modafinil Used More for ADHD?
Modafinil is a eugeroic—a wakefulness agent that tickles the dopamine transporter and activates orexin neurons. It looks like an ADHD drug on paper, but clinical trials consistently show it's inferior to first-line stimulants. This episode unpacks the pharmacology, the clinical evidence, and the one scenario where modafinil might still have a role: comorbid ADHD and depression. We explore why a drug that works well for narcolepsy never crossed over. Episode 3248 — myweirdprompts.com/n/3248 (permanent short link: myweirdprompts.com/453335)
The skinny
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