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Why Most Depression Is Unipolar
Why is unipolar depression so much more common than bipolar disorder — and what keeps most depressed brains from swinging into mania? This episode unpacks the biology behind the prevalence gap. We explore heritability differences (bipolar is 60-85% genetic, unipolar ~37%), structural brain distinctions like prefrontal cortex thinning in the pars orbitalis and pars triangularis, and the dopamine surge unique to mania. We also examine the messy overlap: 40-60% of bipolar patients are initially misdiagnosed with unipolar depression, and ADHD’s emotional lability can muddy the picture further. If…
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