When Perimenopause Looks Like Madness (And Your Heart Knows It Too)

Hot Flasher · Jun 26, 2026 · 9m

This episode digs into a striking case study linking perimenopause to neuroinflammation and late-onset mania — and asks why psychiatry so rarely looks at hormonal transitions when a woman presents with new-onset psychiatric symptoms. We also get into the emerging science of how estrogen loss affects blood pressure regulation, and flag a new retrospective study on a rare but aggressive breast cancer subtype. Key Takeaways: • A 2026 case study proposes that perimenopause-driven neuroinflammation may be a trigger for late-onset mania in women with no prior psychiatric history — and that…