Gut-Brain Drugs: Why Old Antidepressants Help Bloating
A listener wrote in after being prescribed low-dose amitriptyline for bloating and fullness that have followed him since his gallbladder came out seven years ago. It didn't do much — so he came back with three sharp questions: what's the actual mechanism, why are the old tricyclics still the go-to drugs despite their side effects, and is anything new being designed specifically for functional dyspepsia? This episode works through the gut-brain axis, visceral hypersensitivity, gastric accommodation, and the duodenal frontier, and lands on an uncomfortable finding: the drugs that work are the…
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