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Do ADHD Drug Holidays Actually Work?
Is taking weekend breaks from ADHD medication a smart way to prevent tolerance, or is it pop neuroscience with no real evidence? This episode dives into the actual pharmacology of stimulant tolerance, what PET imaging shows about dopamine receptor changes at therapeutic doses, and why the original rationale for drug holidays had nothing to do with dopamine. We also explore the lived reality of involuntary medication gaps, the difference between the honeymoon period and treatment failure, and whether the strongest case for drug holidays is really about side effect management rather than…
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