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Why the Last Milligrams Are the Hardest
Getting off a medication safely is often harder than starting it — and the final milligrams are the most destabilizing of all. This episode digs into the hyperbolic shape of dose-response curves, why alternate-day dosing can backfire, and how Dutch tapering strips solved the precision problem with custom-mixed doses down to fractions of a milligram. We also look at the evidence behind tapering strips, the access and cost barriers that keep them out of reach for many patients, and the emerging 3D-printed compounding efforts in Sweden, Estonia, and Toronto that could finally make personalized…
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