The Atopic March: Why It Stays on the Skin-Lung-Nose Track

Logosofia no Dia a Dia · Jun 13, 2026 · 29m

The atopic march—eczema to asthma to allergies—seems like a predictable path, but why doesn’t it ever lead to rheumatoid arthritis or lupus? This episode unpacks the immune system’s two distinct misbehavior modes: type two inflammation (atopy) versus Th1/Th17 pathways (autoimmunity). We explore the "leaky skin" hypothesis, the role of epithelial barriers, and why the march can sometimes reverse direction. Discover how filaggrin mutations, environmental triggers, and age-related barrier changes determine which organ expresses the atopic predisposition. Plus, we examine why drugs like dupilumab…