When Depression Looks Like Anger

Logosofia no Dia a Dia · Jun 13, 2026 · 33m

Depression doesn't always look like sadness. For a significant subset of patients — especially men — the dominant symptom is irritability, anger, and explosive frustration. Despite decades of clinical awareness since the concept of "masked depression" was introduced in the 1960s, standard screening tools like the PHQ-9 contain zero questions about anger. This episode unpacks the neurobiology behind two distinct pathways that produce angry depression — one involving serotonin and impulse control, another involving cortisol and hyperarousal — and explains why the CDC reports a 37% increase in…