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The Split in Insomnia Treatment: SOI vs SMI
Most people think insomnia is one condition, but the biology tells a different story. Sleep-onset insomnia and sleep-maintenance insomnia involve different brain circuits, different neurotransmitters, and different timing of dysfunction. The FDA just approved a new dual orexin receptor antagonist in March 2026 targeting sleep maintenance specifically, and the treatment pipeline is finally splitting. We break down the neurobiology, the pharmacology, and why your sleeping pill might be targeting the wrong problem. Episode 3166 — myweirdprompts.com/n/3166 (permanent short link…
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