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When a Single Patient Changes Medicine: Case Reports That Matter
Case reports sit at the bottom of medicine’s evidence hierarchy, yet they account for 12% of all PubMed publications. This episode explores why physicians write them (academic currency, naming rights, journal economics) and how humble observations have sparked FDA-approved treatments — from hydroxychloroquine for porphyria to esketamine for depression. We examine the tension between “interestingness” and importance, the role of post-marketing surveillance, and whether the system generates too much noise. Episode 3254 — myweirdprompts.com/n/3254 (permanent short link: myweirdprompts.com/820838)
The skinny
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