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Do Brain Changes from Therapy or Pills Actually Last?
When you stop taking an SSRI, do the brain changes it helped create disappear? And can talk therapy produce physical rewiring that sticks around long after you leave the therapist's office? This episode unpacks the neuroscience behind two listener questions that turn out to be deeply connected. We explore the neuroplasticity hypothesis of antidepressants — why the drug's chemical scaffolding doesn't always lead to lasting structural change, and why 40-60% of patients relapse within a year of discontinuation. Then we examine the growing body of imaging studies showing that cognitive…
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